Jill's Jottings September 2015
This article appeared in Deafness Forum of Australia's newsletter OneInSix (27-5-15).
I found it fascinating – hope you do too – as it tells us more about our wonderful bodies, and our awesome auditory system.
“Researchers at Karolinska Institute in Sweden have identified a biological circadian clock in the hearing organ, the cochlear. (The cochlear is about the size of a pea!) This circadian clock controls how well hearing damage may heal and opens up a new way of treating people with hearing disabilities.
Important body functions, such as sleep, the immune system, and hormone levels are controlled by a biological circadian clock. A team of researchers at Karolinska Institute have now discovered that there is also a biological clock in the ear, controlled by genes known to regulate circadian rhythms. One of these genes was found to cycle in the cochlea from mice over several days, in a pattern that followed the hours of the day.
By measuring the activity of the auditory nerve, the researchers found that mice exposed to moderate noise levels during the night, suffered from permanent hearing damage, while mice exposed to similar noise levels during the day did not. The ability to heal after hearing damage was therefore linked to the time of day during which the noise damage occurred, and here, the ear's circadian clock played an important role.
It is known that the production of the growth hormone, BDNF (Brain-derived Neurotrophic Factor) known to protect auditory nerve cells, fluctuates throughout the day. When mice were exposed to noise during daytime, their concentration of BDNF in the ear increased, which protected them from permanent hearing damage. This protective response was absent at night.
However, researchers succeeded in tricking the mice's ear clocks in an experiment where they exposed mice to noise at night while stimulating BDNF at the same time. Mice were then protected from permanent hearing loss as their auditory nerve cells successfully recovered from noise injury.
These exciting new findings about the ear's clock, which is published in the journal Current Biology, may explain why we have different levels of noise sensitivity during different times of the day. The findings pave the way for new treatment methods for hearing damage, which affects between 10 and 15% of the population. The results are for example, important for shift workers in noisy environments, flight crews that travel quickly across time zones, and people visiting concerts and discos with high noise levels”.
Incredible isn't it! However – it does NOT remove our responsibility to do what we can to look after and protect our own precious hearing!
Jill Lindley
